Prostate Cases Summary treated by Artesunate IV, during April 2017 ~Dec 2018

Summary of Prostate Cancer Patients

Treatment by Artesunate IV.

April 2017~Dec 2018.

CASES OF Dr .A.SAEED

Compiled by: Dr.HASSAN

Treatment’s Main Drug :Artesunate IV,Dose 2.5~3.5mg/kg/day Orally Ascorbic Acid ,Ferrous Sulp,Cholecalciferol,Vit E in different strengths. Follow up : Oral Artesunate 50 ~100 mg , Ascorbic Acid 0.5 ~1 gm

No of cases of PCa : 20 , during April 2017~Dec 2018

Complete Recovery cases :10

Non Responder cases : 6

Non- Follow up cases : 2 , Discontinued Treatment : 2

Side effects during treatment with Low intensity:

Very rare Side effects of Artesunate Treatment

Prostate cancer Treatment case #4, Aug 2018

Prostate CA case # 4, August 2018

Patient ID : AUG 2/018/PCa-4

Man,62 y,Non smoker

Non-Alcoholic ,Married.

Patient weight : 72 kg

Complaints : Patient haven't control urine ,painful urination.

Burning during urination.

PSA Level : 12 ng/ml

HbA1c Level:  5.8 %

ALT :36 u/L

Creatinine: 1.2 mg/dl

Hb: 10.5

                    9

TLC: 3.2 x10 /L

Vit D Level is 15 ng/ml

URINE Details Reports shows blood + ,Pus Cells 20~25.

Ultrasound : shows Prostate Cancer invades semanil vessels of both sides

as well as start penetration to bladder.

Biopsy Report: Not Available

Treatment  :

Artesunate IV, 2.5 mg/kg/day x OD , Mix with 100 ml NS @ 20 drops per minute , 2 hrs after a light meal.

Cholecalciferol 50000 iu, Orally ,OD

Ascorbic Acid 500 mg,Orally x BD

Ferrous Sulphate 60 mg,Orally x OD

Duration of Treatment:  30 days

Follow up :

Mild Painful urination , No blood in Urine .Good Control of Urine.

PSA Level : 8 ng/ml

Urine detail report Normal.

CBC,LFT Normal limits.

Pre treatment ALT  36 U /L

Post treatment ALT 48 U /L

Side effects during therapy:

Slight increase in ALT level.

Patient complaints mild Nausea and bloating during treatment.

Follow up treatment:

1..Artesunate 50 mg x BD orally

2.. Ascorbic Acid 500 mg X OD orally

For 90 days.

Post treatment PSA level was 7 ng/ml.

The treatment completed in 120 days.

Advised : Monthly follow up consultation for 6 months.

Pre-Treatment scan

This patient want to be clear about that his prostate is normal or not ,

that’s why i advised him  PET CT scan.

FD PET-CT scan shows Prostate ,seminal ves ,bladder are clear.

Prostate Cancer Treatment case # 3,Jun 2017

Prostate CA case # 3, Jun 2017

Patient ID : Jun 2/017/PCa-3

Man,61 y,Non smoker

Non-Alcoholic ,Married.

Patient weight : 68 kg

Complaints : Patient not able to control urine ,Severe painful urination,Blood in urine.

Hb: 10.5

PSA Level : 13 ng/ml

HbA1c Level:  5.2 %

ALT :68 u/L

Creatinine: 1.2 mg/dl

CBC,LFT ,U&C ,Lipid Profile   are in Higher Limits.

Vit D Level is 12 ng/ml

URINE Details Reports shows blood +++ ,Pus Cells 40~45.

Ultrasound : shows Prostatic Hyperplastic  mass.

Biopsy : Squamous Cell Carcinoma of Prostate gland

Treatment  :

Artesunate IV, 3.5 mg/kg/day x OD , Mix with 100 ml NS @ 20 drops per minute , 2 hrs after a light meal.

Cholecalciferol 50000 iu Orally ,OD

Ascorbic Acid 500 mg,Orally x BD

Ferrous Sulphate 60 mg,Orally x OD

Duration of Treatment:  30 days.

Follow up :

Mild Painful urination , blood in Urine .Good Control of Urine.

PSA Level : 9 ng/ml

Puss cell ++ in urine found.

Pre treatment ALT  60 U /L

Post treatment ALT 38 U /L

Side effects during therapy:

Patient complaints headache during treatment.

Ultrasound : Prostatic Mass shows very low density.

Follow up treatment:

1..Artesunate 100 mg x BD orally

2.. Ascorbic Acid 500 mg X BD orally

For 60 days.

Post treatment PSA level was 7 ng/ml.

The treatment completed in 90 days.

Advised : Monthly follow up consultation for 6 months.

Pre-Treatment Scan

Post-Treatment Scan

After 1 year.

Prostate Cancer Treatment Case #2 ,April 2017

Prostate CA case # 2, April 2017

Patient ID : APR 2/017/PCa-2

Man,48y,Non smoker

Non-Alcoholic ,Married,Father of a child.

Patient weight : 78 kg

Complaints : Patient not able to control urine ,painful urination,Blood in urine.

PSA Level : 12 ng/ml

HbA1c Level:  6.2 %

ALT :48 u/L

Creatinine: 0.8 mg/dl

CBC,LFT ,U&C ,Lipid Profile   are in Normal Limits.

Vit D Level is 18 ng/ml

URINE Details Reports shows blood +++ ,Pus Cells 35~40.

Having Kidney stone in Rt kidney 0.6 cm.

Ultrasound : shows Prostatic Hyperplasia with Nodular mass.

Biopsy : Acinar Adenocarcinoma of Prostate

Treatment  :

Artesunate IV, 3 mg/kg/day x OD , Mix with 100 ml NS @ 20 drops per minute , 2 hrs after a light meal.

Vit E 200mg Orally ,OD

Ascorbic Acid 500 mg,Orally x OD

Ferrous Sulphate 60 mg,Orally x OD

Duration of Treatment:  30 days

Specially Advised to stop Sexual intercouse during treatment.

Follow up :

Mild Painful urination , No blood in Urine .Good Control of Urine.

PSA Level : 8 ng/ml

Urine detail report Normal.

Pre treatment ALT  48 U /L

Post treatment ALT 32 U /L

Side effects during therapy:

Patient complaints mild Nausea ,Abdominal cramps during treatment.

Ultrasound : Almost Normal Prostate .Nodules not Visualized.

Follow up treatment:

1..Artesunate 100 mg x BD orally

2.. Ascorbic Acid 500 mg X BD orally

For 45 days.

Post treatment PSA level was 7 ng/ml.

The treatment completed in 75 days.

Advised : Monthly follow up consultation for 6 months.

Pre-treatment Scan

Post- Treatment Scan

The Ideal drug for Cancer Treatment

The ideal Cancer drug must has:

1..Strong Antiproliferative Activity.

2..Rapid Inhibition in cancer cell growth by Cell Cycle Arrest.

3..Induced accurate ROS.

4..Inhibits Angiogenesis and Metastasis.

5..Appoptic induction in CA cells.

6..Less than Lesser side effects ***

7..Availability in ORAL ,IV administrations.

8..Low Priced

9..Broad Spectrum,can be used ALONE & Combination.

10..Strong In Vitro and In Vivo background.

***Current treatment options for  cancer involves
the use of several types of chemotherapeutic agents
,such as paclitaxel, cisplatin, and doxorubicin etc ,
that are efficacious at high doses, but also exhibit
significant adverse side affects such as Liver damage ,
renal damage,Joints distortion, gastrointestinal toxicity,
and bone marrow suppression etc.

A. Saeed ,May2019.

A short summary of the history of ARTEMISIA

A short brief Note about Artemisia:

Naturally occurring plant compounds represent a largely untapped source of potential chemotherapeutic molecules to control different types of cancers with very minimal side effects.

One such phytochemical is artemisinin, which is a sequiterpene lactone that was isolated from the aerial portions of the Artemisia annua plant (more commonly known as Afsanteen or sweet wormwood for more than 3000 years in AYURVEDA, the Traditional Medicinal System of Treatment in sub-continant ).
The seeds of ARTMESIA are freely available in Pakistan,Iran, India,Bangladesh with the name" Khak-seer ".
Artemesia plant was discovered by PROPHET ENOCH (HAZRAT IDRESS AS) .He used Artemisia for Wounds and Fevers 7000 years BC .

The sub­­-continant practitioners have utilized this herb in dried form of whole plant or boiling the dried herb or to make paste of fresh plant to treat a variety of illnesses, such as intestinal parasitic infections, hemorrhoids,Wounds and fever for about 3000 years .
Amazingly, i found that the people of Iran, Tajikistan ,Uzbekistan and some provinces of Afghanistan i.e Qunduz, Tahkhar,Mazar e shareef are taking fresh & newly grow Artemesia Leaves with cucumber,carrot,Onion etc as Salad with food.
When I was collecting data for these countries where people used Artemisia as salad,amzzingly i came to know that the Cancer is very very rare in these countries.But that will be more investigated for further Research on Artemisia.

Artemisia is not a Chinese herb ,but it is found in china as well as found in Africa,South America,Europe,Asia as such a global medicinal plant.In Africa and Asia Artemisia is used for fevers and wound from thousands of years. Artemisia is one of the mainstream drugs used in sub continant medicinal system and have very good results.

The chinese scientist discoverd the mode of action of Artemisia in 1972 ,prof Tu yu yu and her team made this great achievement and honoured a Nobel Prize in 2015 but the Chinese claim is wrong that Artemisia is a chinese medicinal plant.

In 1876~98 some German Chemists worked on Artemisia but unfortunately their work is no longer availabe after world war II.





A.Saeed, May 2019