Prostate Cases Summary treated by Artesunate IV, during April 2017 ~Dec 2018

Summary of Prostate Cancer Patients

Treatment by Artesunate IV.

April 2017~Dec 2018.

CASES OF Dr .A.SAEED

Compiled by: Dr.HASSAN

Treatment’s Main Drug :Artesunate IV,Dose 2.5~3.5mg/kg/day Orally Ascorbic Acid ,Ferrous Sulp,Cholecalciferol,Vit E in different strengths. Follow up : Oral Artesunate 50 ~100 mg , Ascorbic Acid 0.5 ~1 gm

No of cases of PCa : 20 , during April 2017~Dec 2018

Complete Recovery cases :10

Non Responder cases : 6

Non- Follow up cases : 2 , Discontinued Treatment : 2

Side effects during treatment with Low intensity:

Very rare Side effects of Artesunate Treatment

Prostate cancer Treatment case #4, Aug 2018

Prostate CA case # 4, August 2018

Patient ID : AUG 2/018/PCa-4

Man,62 y,Non smoker

Non-Alcoholic ,Married.

Patient weight : 72 kg

Complaints : Patient haven't control urine ,painful urination.

Burning during urination.

PSA Level : 12 ng/ml

HbA1c Level:  5.8 %

ALT :36 u/L

Creatinine: 1.2 mg/dl

Hb: 10.5

                    9

TLC: 3.2 x10 /L

Vit D Level is 15 ng/ml

URINE Details Reports shows blood + ,Pus Cells 20~25.

Ultrasound : shows Prostate Cancer invades semanil vessels of both sides

as well as start penetration to bladder.

Biopsy Report: Not Available

Treatment  :

Artesunate IV, 2.5 mg/kg/day x OD , Mix with 100 ml NS @ 20 drops per minute , 2 hrs after a light meal.

Cholecalciferol 50000 iu, Orally ,OD

Ascorbic Acid 500 mg,Orally x BD

Ferrous Sulphate 60 mg,Orally x OD

Duration of Treatment:  30 days

Follow up :

Mild Painful urination , No blood in Urine .Good Control of Urine.

PSA Level : 8 ng/ml

Urine detail report Normal.

CBC,LFT Normal limits.

Pre treatment ALT  36 U /L

Post treatment ALT 48 U /L

Side effects during therapy:

Slight increase in ALT level.

Patient complaints mild Nausea and bloating during treatment.

Follow up treatment:

1..Artesunate 50 mg x BD orally

2.. Ascorbic Acid 500 mg X OD orally

For 90 days.

Post treatment PSA level was 7 ng/ml.

The treatment completed in 120 days.

Advised : Monthly follow up consultation for 6 months.

Pre-Treatment scan

This patient want to be clear about that his prostate is normal or not ,

that’s why i advised him  PET CT scan.

FD PET-CT scan shows Prostate ,seminal ves ,bladder are clear.

Prostate Cancer Treatment case # 3,Jun 2017

Prostate CA case # 3, Jun 2017

Patient ID : Jun 2/017/PCa-3

Man,61 y,Non smoker

Non-Alcoholic ,Married.

Patient weight : 68 kg

Complaints : Patient not able to control urine ,Severe painful urination,Blood in urine.

Hb: 10.5

PSA Level : 13 ng/ml

HbA1c Level:  5.2 %

ALT :68 u/L

Creatinine: 1.2 mg/dl

CBC,LFT ,U&C ,Lipid Profile   are in Higher Limits.

Vit D Level is 12 ng/ml

URINE Details Reports shows blood +++ ,Pus Cells 40~45.

Ultrasound : shows Prostatic Hyperplastic  mass.

Biopsy : Squamous Cell Carcinoma of Prostate gland

Treatment  :

Artesunate IV, 3.5 mg/kg/day x OD , Mix with 100 ml NS @ 20 drops per minute , 2 hrs after a light meal.

Cholecalciferol 50000 iu Orally ,OD

Ascorbic Acid 500 mg,Orally x BD

Ferrous Sulphate 60 mg,Orally x OD

Duration of Treatment:  30 days.

Follow up :

Mild Painful urination , blood in Urine .Good Control of Urine.

PSA Level : 9 ng/ml

Puss cell ++ in urine found.

Pre treatment ALT  60 U /L

Post treatment ALT 38 U /L

Side effects during therapy:

Patient complaints headache during treatment.

Ultrasound : Prostatic Mass shows very low density.

Follow up treatment:

1..Artesunate 100 mg x BD orally

2.. Ascorbic Acid 500 mg X BD orally

For 60 days.

Post treatment PSA level was 7 ng/ml.

The treatment completed in 90 days.

Advised : Monthly follow up consultation for 6 months.

Pre-Treatment Scan

Post-Treatment Scan

After 1 year.

Prostate Cancer Treatment Case #2 ,April 2017

Prostate CA case # 2, April 2017

Patient ID : APR 2/017/PCa-2

Man,48y,Non smoker

Non-Alcoholic ,Married,Father of a child.

Patient weight : 78 kg

Complaints : Patient not able to control urine ,painful urination,Blood in urine.

PSA Level : 12 ng/ml

HbA1c Level:  6.2 %

ALT :48 u/L

Creatinine: 0.8 mg/dl

CBC,LFT ,U&C ,Lipid Profile   are in Normal Limits.

Vit D Level is 18 ng/ml

URINE Details Reports shows blood +++ ,Pus Cells 35~40.

Having Kidney stone in Rt kidney 0.6 cm.

Ultrasound : shows Prostatic Hyperplasia with Nodular mass.

Biopsy : Acinar Adenocarcinoma of Prostate

Treatment  :

Artesunate IV, 3 mg/kg/day x OD , Mix with 100 ml NS @ 20 drops per minute , 2 hrs after a light meal.

Vit E 200mg Orally ,OD

Ascorbic Acid 500 mg,Orally x OD

Ferrous Sulphate 60 mg,Orally x OD

Duration of Treatment:  30 days

Specially Advised to stop Sexual intercouse during treatment.

Follow up :

Mild Painful urination , No blood in Urine .Good Control of Urine.

PSA Level : 8 ng/ml

Urine detail report Normal.

Pre treatment ALT  48 U /L

Post treatment ALT 32 U /L

Side effects during therapy:

Patient complaints mild Nausea ,Abdominal cramps during treatment.

Ultrasound : Almost Normal Prostate .Nodules not Visualized.

Follow up treatment:

1..Artesunate 100 mg x BD orally

2.. Ascorbic Acid 500 mg X BD orally

For 45 days.

Post treatment PSA level was 7 ng/ml.

The treatment completed in 75 days.

Advised : Monthly follow up consultation for 6 months.

Pre-treatment Scan

Post- Treatment Scan

The Ideal drug for Cancer Treatment

The ideal Cancer drug must has:

1..Strong Antiproliferative Activity.

2..Rapid Inhibition in cancer cell growth by Cell Cycle Arrest.

3..Induced accurate ROS.

4..Inhibits Angiogenesis and Metastasis.

5..Appoptic induction in CA cells.

6..Less than Lesser side effects ***

7..Availability in ORAL ,IV administrations.

8..Low Priced

9..Broad Spectrum,can be used ALONE & Combination.

10..Strong In Vitro and In Vivo background.

***Current treatment options for  cancer involves
the use of several types of chemotherapeutic agents
,such as paclitaxel, cisplatin, and doxorubicin etc ,
that are efficacious at high doses, but also exhibit
significant adverse side affects such as Liver damage ,
renal damage,Joints distortion, gastrointestinal toxicity,
and bone marrow suppression etc.

A. Saeed ,May2019.

Prostate Cancer Treatment Case # 1, April 2017

Prostate CA case # 1, April 2017

Patient ID : APR 2/017/PCa-1

Man,52 y,Smoker,

Non-Alcoholic ,Married,Father of 3 children.

Complaints : painful urination,Blood in urine.

PSA Level : 14 ng/ml

HbA1c Level:  5.4 %

ALT : 25 u/L

Creatinine: 1.1 mg/dl

CBC,LFT ,U&C ,Lipid Profile   are in Normal Limits.

Vit D Level is 15 ng/ml

URINE Details Reports shows blood +++ ,Pus Cells 20~25.

Ultrasound : shows Small Cell Carcinoma of Prostate.

Treatment  :

Artesunate IV, 2.5 mg/kg/day x OD , Mix with 100 ml NS @ 20 drops per minute , 2 hrs after a light meal.

Cholecalciferol 50000 iu,Orally ,OD

Ascorbic Acid 500 mg,Orally x BD

Ferrous Sulphate 60 mg,Orally x OD

Duration of Treatment:  30 days

Specially Advised to stop smoking ,Sexual intercouse during treatment.

Follow up :

No Painful urination , No blood in Urine .

PSA Level : 10 ng/ml

Urine detail report Normal.

Slight increase shown in ALT level

Pre treatment ALT  25 U /L

Post treatment ALT 42  U /L

Side effects during therapy:

Patient complaints mild Nausea ,Dizziness during treatment.

Ultrasound : Almost Normal Prostate .

Follow up treatment:

1..Artesunate 50 mg x BD orally

2.. Ascorbic Acid 500 mg X BD orally

For 60 days.

Post treatment PSA level was 8 ng/ml.

The treatment completed in 90 day.

Advised : Monthly follow up consultation for 6 months.

Pre-Treatment Scan.

Post Treatment Scan.