Higher Doses of Artesunate IV with Iron Sucrose IV in Prostate Cancer Patients.
A.Saeed ,July 2019
Artesunate IV at Higher Doses i.e 8~12 mg/kg/day with Iron Sucrose IV 0.5~1 mg/kg /day
regimen may be use for much better and quick results for Prostate Cancer patients are required to evaluate the efficacy of this regimen.
Remember this will be the the Single Drug regimen for Prostate Cancer.
An Study published that the usage of Artesunate IV in a dose of 12 mg/kg @0,12,24,48 & 72
hours.[1] for Severe Falcip Malaria patient as Artemisinin firstly used for Malaria patient world wide .
https://www.reliasmedia.com/articles/77347-an-alternate-effective-dosing-regimen-for-iv-artesunate
It means that Artesunate IV is safe at higher doses up to 12 mg/kg/day.
Thursday, 4 July 2019
Monday, 6 May 2019
Prostate Cases Summary treated by Artesunate IV, during April 2017 ~Dec 2018
Summary of Prostate Cancer Patients
Treatment by Artesunate IV.
April 2017~Dec 2018.
CASES OF Dr .A.SAEED
Compiled by: Dr.HASSAN
Treatment’s Main Drug :Artesunate IV,Dose 2.5~3.5mg/kg/day
Orally Ascorbic Acid ,Ferrous Sulp,Cholecalciferol,Vit E in different strengths.
Follow up : Oral Artesunate 50 ~100 mg , Ascorbic Acid 0.5 ~1 gm
|
No of cases of PCa : 20 , during April 2017~Dec 2018
|
Complete Recovery cases :10
|
Non Responder cases : 6
|
Non- Follow up cases : 2 , Discontinued Treatment : 2
|
Side effects during treatment with Low intensity:
 |
| Very rare Side effects of Artesunate Treatment |
Prostate cancer Treatment case #4, Aug 2018
Prostate CA case # 4, August 2018
Patient ID : AUG 2/018/PCa-4
Man,62 y,Non smoker
Non-Alcoholic ,Married.
Patient weight : 72 kg
Complaints : Patient haven't control urine ,painful urination.
Burning during urination.
PSA Level : 12 ng/ml
HbA1c Level: 5.8 %
ALT :36 u/L
Creatinine: 1.2 mg/dl
Hb: 10.5
9
TLC: 3.2 x10 /L
Vit D Level is 15 ng/ml
URINE Details Reports shows blood + ,Pus Cells 20~25.
Ultrasound : shows Prostate Cancer invades semanil vessels of both sides
as well as start penetration to bladder.
Biopsy Report: Not Available
Treatment :
Artesunate IV, 2.5 mg/kg/day x OD ,
Mix with 100 ml NS @ 20 drops per minute ,
2 hrs after a light meal.
|
Cholecalciferol 50000 iu, Orally ,OD
|
Ascorbic Acid 500 mg,Orally x BD
|
Ferrous Sulphate 60 mg,Orally x OD
|
Duration of Treatment: 30 days
Follow up :
Mild Painful urination , No blood in Urine .Good Control of Urine.
PSA Level : 8 ng/ml
Urine detail report Normal.
CBC,LFT Normal limits.
Pre treatment ALT 36 U /L
Post treatment ALT 48 U /L
Side effects during therapy:
Slight increase in ALT level.
Patient complaints mild Nausea and bloating during treatment.
Follow up treatment:
1..Artesunate 50 mg x BD orally
2.. Ascorbic Acid 500 mg X OD orally
For 90 days.
Post treatment PSA level was 7 ng/ml.
The treatment completed in 120 days.
Advised : Monthly follow up consultation for 6 months.
Pre-Treatment scan
This patient want to be clear about that his prostate is normal or not ,
that’s why i advised him PET CT scan.
FD PET-CT scan shows Prostate ,seminal ves ,bladder are clear.
Prostate Cancer Treatment case # 3,Jun 2017
Prostate CA case # 3, Jun 2017
Patient ID : Jun 2/017/PCa-3
Man,61 y,Non smoker
Non-Alcoholic ,Married.
Patient weight : 68 kg
Complaints : Patient not able to control urine ,Severe painful urination,Blood in urine.
Hb: 10.5
PSA Level : 13 ng/ml
HbA1c Level: 5.2 %
ALT :68 u/L
Creatinine: 1.2 mg/dl
CBC,LFT ,U&C ,Lipid Profile are in Higher Limits.
Vit D Level is 12 ng/ml
URINE Details Reports shows blood +++ ,Pus Cells 40~45.
Ultrasound : shows Prostatic Hyperplastic mass.
Biopsy : Squamous Cell Carcinoma of Prostate gland
Treatment :
Artesunate IV, 3.5 mg/kg/day x OD ,
Mix with 100 ml NS @ 20 drops per minute ,
2 hrs after a light meal.
|
Cholecalciferol 50000 iu Orally ,OD
|
Ascorbic Acid 500 mg,Orally x BD
|
Ferrous Sulphate 60 mg,Orally x OD
|
Duration of Treatment: 30 days.
Follow up :
Mild Painful urination , blood in Urine .Good Control of Urine.
PSA Level : 9 ng/ml
Puss cell ++ in urine found.
Pre treatment ALT 60 U /L
Post treatment ALT 38 U /L
Side effects during therapy:
Patient complaints headache during treatment.
Ultrasound : Prostatic Mass shows very low density.
Follow up treatment:
1..Artesunate 100 mg x BD orally
2.. Ascorbic Acid 500 mg X BD orally
For 60 days.
Post treatment PSA level was 7 ng/ml.
The treatment completed in 90 days.
Advised : Monthly follow up consultation for 6 months.
Pre-Treatment Scan
Post-Treatment Scan
After 1 year.
Prostate Cancer Treatment Case #2 ,April 2017
Prostate CA case # 2, April 2017
Patient ID : APR 2/017/PCa-2
Man,48y,Non smoker
Non-Alcoholic ,Married,Father of a child.
Patient weight : 78 kg
Complaints : Patient not able to control urine ,painful urination,Blood in urine.
PSA Level : 12 ng/ml
HbA1c Level: 6.2 %
ALT :48 u/L
Creatinine: 0.8 mg/dl
CBC,LFT ,U&C ,Lipid Profile are in Normal Limits.
Vit D Level is 18 ng/ml
URINE Details Reports shows blood +++ ,Pus Cells 35~40.
Having Kidney stone in Rt kidney 0.6 cm.
Ultrasound : shows Prostatic Hyperplasia with Nodular mass.
Biopsy : Acinar Adenocarcinoma of Prostate
Treatment :
Artesunate IV, 3 mg/kg/day x OD ,
Mix with 100 ml NS @ 20 drops per minute ,
2 hrs after a light meal.
|
Vit E 200mg Orally ,OD
|
Ascorbic Acid 500 mg,Orally x OD
|
Ferrous Sulphate 60 mg,Orally x OD
|
Duration of Treatment: 30 days
Specially Advised to stop Sexual intercouse during treatment.
Follow up :
Mild Painful urination , No blood in Urine .Good Control of Urine.
PSA Level : 8 ng/ml
Urine detail report Normal.
Pre treatment ALT 48 U /L
Post treatment ALT 32 U /L
Side effects during therapy:
Patient complaints mild Nausea ,Abdominal cramps during treatment.
Ultrasound : Almost Normal Prostate .Nodules not Visualized.
Follow up treatment:
1..Artesunate 100 mg x BD orally
2.. Ascorbic Acid 500 mg X BD orally
For 45 days.
Post treatment PSA level was 7 ng/ml.
The treatment completed in 75 days.
Advised : Monthly follow up consultation for 6 months.
Pre-treatment Scan
Post- Treatment Scan
Sunday, 5 May 2019
The Ideal drug for Cancer Treatment
The ideal Cancer drug must has:
1..Strong Antiproliferative Activity.
2..Rapid Inhibition in cancer cell growth by Cell Cycle Arrest.
3..Induced accurate ROS.
4..Inhibits Angiogenesis and Metastasis.
5..Appoptic induction in CA cells.
6..Less than Lesser side effects ***
7..Availability in ORAL ,IV administrations.
8..Low Priced
9..Broad Spectrum,can be used ALONE & Combination.
10..Strong In Vitro and In Vivo background.
***Current treatment options for cancer involves
the use of several types of chemotherapeutic agents
,such as paclitaxel, cisplatin, and doxorubicin etc ,
that are efficacious at high doses, but also exhibit
significant adverse side affects such as Liver damage ,
renal damage,Joints distortion, gastrointestinal toxicity,
and bone marrow suppression etc.
the use of several types of chemotherapeutic agents
,such as paclitaxel, cisplatin, and doxorubicin etc ,
that are efficacious at high doses, but also exhibit
significant adverse side affects such as Liver damage ,
renal damage,Joints distortion, gastrointestinal toxicity,
and bone marrow suppression etc.
A. Saeed ,May2019.
Prostate Cancer Treatment Case # 1, April 2017
Prostate CA case # 1, April 2017
Patient ID : APR 2/017/PCa-1
Man,52 y,Smoker,
Non-Alcoholic ,Married,Father of 3 children.
Complaints : painful urination,Blood in urine.
PSA Level : 14 ng/ml
HbA1c Level: 5.4 %
ALT : 25 u/L
Creatinine: 1.1 mg/dl
CBC,LFT ,U&C ,Lipid Profile are in Normal Limits.
Vit D Level is 15 ng/ml
URINE Details Reports shows blood +++ ,Pus Cells 20~25.
Ultrasound : shows Small Cell Carcinoma of Prostate.
Treatment :
Artesunate IV, 2.5 mg/kg/day x OD ,
Mix with 100 ml NS @ 20 drops per minute ,
2 hrs after a light meal.
|
Cholecalciferol 50000 iu,Orally ,OD
|
Ascorbic Acid 500 mg,Orally x BD
|
Ferrous Sulphate 60 mg,Orally x OD
|
Duration of Treatment: 30 days
Specially Advised to stop smoking ,Sexual intercouse during treatment.
Follow up :
No Painful urination , No blood in Urine .
PSA Level : 10 ng/ml
Urine detail report Normal.
Slight increase shown in ALT level
Pre treatment ALT 25 U /L
Post treatment ALT 42 U /L
Side effects during therapy:
Patient complaints mild Nausea ,Dizziness during treatment.
Ultrasound : Almost Normal Prostate .
Follow up treatment:
1..Artesunate 50 mg x BD orally
2.. Ascorbic Acid 500 mg X BD orally
For 60 days.
Post treatment PSA level was 8 ng/ml.
The treatment completed in 90 day.
Advised : Monthly follow up consultation for 6 months.
Pre-Treatment Scan.
Post Treatment Scan.
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